While the role of barrier function in establishing a protective, nutrient-rich, and ionically balanced environment for neurons has been appreciated for some time, little is known about how signaling ...

Thus, the present study has shown that d-Asb11 is a positive regulator of Notch signalling, probably acting at the level of DeltaA ubiquitylation and thereby regulating Notch signalling activity in a ...

本研究针对动态组织中细胞命运如何实现精确模式形成这一发育生物学核心问题，以果蝇蛹期翅膀翅脉 refinemen 为模型，通过活体成像发现 Notch 信号波协同 EGFR 和 Dpp 信号通路自主驱动 provein 精细化过程，与大规模组织流无关。研究人员构建数学模型并结合光 ...

A report in the January 24 online Journal of Biological Chemistry indicates that the Notch ligands Delta and Jagged are also substrates for γ-secretase, the intramembrane aspartyl protease responsible ...