细胞重编程可通过调控细胞命运，诱导获得适用于临床治疗的目标细胞类型，开辟了再生医学新的路径。2006年，日本科学家山中伸弥（Shinya Yamanaka）借助病毒载体将Oct4、Sox2、Klf4和c-Myc四个转录因子（OSKM，即“山中因子”）导入成体细胞，将其重编程为诱导多能干细胞（iPS细胞），是生命科学研究里程碑式的突破。

A single-atom nanozyme mimicking cytochrome c oxidase restores mitochondrial energy production in stem cells, shifting their ...

Stress fiber–generated traction forces critically regulate mesenchymal stem cell (MSC) behavior, yet how mechanical cues are ...

Mineral casts of cancer cell surfaces reprogram fat cells into stem cells and improve insulin sensitivity in obese mice ...

From billionaire-backed biotech to promising animal studies, this early trial will test whether partial reprogramming can ...

Scientists at University of California San Diego have developed a new approach to destroying cancer stem cells – hard-to-find cells that help cancers spread, come back after treatment and resist ...

A burgeoning field is launching its first clinical trial to find out whether dialing back cell development can safely refresh ...

Aside from reprogramming and transdifferentiation, the longer-existing approach to generating neurons and NSCs has been differentiating them from pluripotent cells, initially from embryonic stem cells ...

This article was published in Scientific American’s former blog network and reflects the views of the author, not necessarily those of Scientific American NEW YORK—Despite a cloud of regulatory ...

BLOOM (TAMPA) – Health and lifestyle expert Dr. Fabrizio “Dr. Fab” Mancini—known for more than 30 years of experience as a holistic health provider—joined Gayle Guyardo on the globally syndicated ...