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单基因座染色质构象的概率推断:PLOTTED技术揭示发育中染色质动态与 ...
本研究针对染色质三维构象动态难以直接测量的问题,开发了PLOTTED(Probabilistic Localization of Oligopaint Tagged Target Element Distances)技术,通过整合超分辨成像与计算分析,实现了对单个基因座内顺式调控模块(CRMs)空间距离的概率化建模。研究以果蝇brinker(brk)基 ...
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