Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands ...

CRISPR/Cas9 technology has the potential to significantly enhance plant breeding. To determine the specificity and the mutagenic spectrum of SpCas9 in tomato, we ...

Large paralogous protein families are found throughout biology, the product of extensive gene duplication. To execute different functions inside cells, paralogs often acquire different specificities, ...

The brain encodes the statistical regularities of the environment in a task-specific yet flexible and generalizable format. Here, we seek to understand this process by bridging two parallel lines of ...

Vascular smooth muscle cells (VSMCs) phenotype switch from contractile to proliferative phenotype is a pathological hallmark in various cardiovascular diseases. Recently, a subset of long noncoding ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Single-target quantitative polymerase chain reaction (qPCR) is ...

Encoding models for mapping voxelwise semantic tuning are typically estimated separately for each individual, limiting their generalizability. In the current report, we develop a method for estimating ...

Nucleic acids are essential biomolecules, encoding and regulating the expression of hereditary information within living organisms 1. The biological importance of nucleic acids has prompted the use of ...