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Increased levels of miR-34a block its target gene CDK4, thereby obstructing cell cycle progression ( 81 ). Altogether, indole-3-carbinol demonstrated a multifaceted anticancer effect and enhances ...
Loss of SNORD50A and SNORD50B increased the amount of GTP-bound, active K-Ras and hyperactivated Ras-ERK1/ERK2 signaling. Given RAS pathway alterations in pediatric neuroblastoma (ALK mutations), ...
The kinetochore is a large proteinaceous structure that mediates interactions between chromosomal DNA and spindle-microtubule polymers. More than 80 kinetochore proteins have been identified using ...
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