A new multiplex immunofluorescence workflow using standard laboratory equipment and open-source software enables detailed ...

Over the past two decades, high‑throughput sequencing has dramatically expanded our understanding of the gut microbiome's composition.

无颌脊椎动物七鳃鳗的大脑相对简单，了解其工作原理可能为脊椎动物大脑进化提供宝贵见解。研究者结合单核RNA测序和空间转录组学技术，构建了成年七鳃鳗大脑的三维图谱。

Study: Common polyethylene microplastics may worsen fatty liver disease. In mice on high-fat diets, exposure doubled liver ...

Researchers at The University of Texas MD Anderson Cancer Center have developed a spatial map of muscle-invasive bladder cancer, revealing how tumor cell states, immune environments and therapeutic ...

The gut microbiome is not a mere spectator but an active player in colorectal cancer (CRC), driving tumor initiation and ...

Trends in liver metastases at diagnosis among young adults with colorectal cancer: A SEER-based analysis, 2010–2022. Genotype-directed targeted therapy combined with HAIC and tislelizumab for ...

A novel spatial transcriptomics atlas developed by Northwestern Medicine scientists may improve the understanding of niche cellular interactions in the gastrointestinal tract that promote the ...

Abstract: Clustering individual cells or spots based on their gene expression profiles in a spatial context is a powerful approach to uncovering the underlying biological diversity and relationships ...

Spatial biology is a rapidly advancing discipline that examines biological molecules (such as DNA, RNA, and proteins) within their native locations in tissues. This approach offers critical insight ...

In 2021, a technology developed at University of Michigan, called Seq-Scope, revolutionized the ability to map gene activity within intact tissue at microscopic resolution, enabling researchers to ...

Lymph nodes are key sites of adaptive immune responses, yet how immune cells coordinate their activities in space and time remains poorly understood. We combined high-resolution spatial ...