A new form of CAR T-cell therapy has been designed to find and destroy the cancer-driving stem cells responsible for a group of blood cancers known as myeloproliferative neoplasms (MPNs), while ...

Signal transduction and gene regulation are at the heart of cell and developmental biology, driving cell fate decisions and tissue homeostasis. In cancer, ...

A new study has demonstrated that colon cancer cells may change identity to metastasize. Loss of GATA6, a transcription factor that controls which genes are turned on or off, can reprogram colorectal ...

A new study suggests low-intensity ultrasound can influence immune cell behavior in ways that may reduce chronic inflammation ...

Contributed by Myles Brown, November 6, 2019 (sent for review July 9, 2019; reviewed by Douglas Yee and Wilbert Zwart) In this study, we integrated FOXA1 cistrome, epigenetic histone marks, and ...

Hypertrophic scars (HS) are abnormal outcomes of wound healing, marked by excessive extracellular matrix (ECM) deposition and ...

The first Antibody-drug conjugate (ADC) was approved overa quarter-century ago, and today more than 20 have reached the clinic.

A new international clinical intervention study published in Clinical Nutrition reveals the molecular and transcriptomic mechanisms through which a dietary intervention may beneficially influence gene ...

Bacterial wilt is a devastating vascular disease caused by Ralstonia solanacearum that infests a remarkably broad range of over 250 plant species, including important Solanaceae crops such as tomato, ...

During direct cardiac reprogramming, cardiogenic transcription factors (TFs) cooperatively reshape the epigenomic landscape by activating cardiac enhancers, which describe a common epigenetic ...