空间转录组学（Spatial transcriptomics）仍然受限于成本、设备负担，以及对小区域感兴趣区（ROI）内预定义低丰度靶标检测效率不足。研究人员提出GLASS-seq（凝胶锚定、连接辅助、可扩展空间测序，Gel-anchored, Ligatio ...

This is our PyTorch implementation for the paper: Tinglin Huang, Tianyu Liu, Mehrtash Babadi, Rex Ying, and Wengong Jin (2025). STPath: A Generative Foundation Model for Integrating Spatial ...

Objective Hepatitis B virus (HBV) can integrate into the chromosomes of infected hepatocytes, contributing to the production of hepatitis B surface antigen (HBsAg) and to hepatocarcinogenesis. In this ...

scPairs is an R package for the systematic identification and multi-evidence evaluation of synergistic gene pairs in single-cell and spatial transcriptomics data. Unlike conventional pairwise ...

aDivision of Rheumatology, Department of Internal Medicine, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, 510630, China bDepartment of Endocrinology and Metabolism, ...

Lymph nodes are key sites of adaptive immune responses, yet how immune cells coordinate their activities in space and time remains poorly understood. We combined high-resolution spatial ...

Background Most patients with biliary tract cancer (BTC) do not derive durable clinical benefit (DCB) from immune checkpoint inhibitors (ICIs), underscoring the urgent need for predictive biomarkers.

Abstract: Spatial transcriptomics (ST), known as an expensive medical examination, plays an important role in analyzing the spatial heterogeneity of tumors. When considering the correlation between ...

More than half of patients with ischemic stroke experience futile reperfusion, increasing the risk of death and disabilities despite a successful recanalization. The reason behind this is debated, and ...